渗透性

 渗透性

 

描述

由于三维体外组织模型与人正常皮肤非常接近,可以在组织模型表面涂抹原料、化学品或成品,用共聚拉曼光谱或液相色谱法检测样品的渗透。

 

模型

   EpiSkinTM 表皮模型
   SkinEthicTM RHE 表皮模型
   T-SkinTM 全皮模型

 

 

详细实验步骤

  • 渗透性实验(点击此处下载)

 

参考文献

Comparison of xenobiotic metabolizing enzyme activities in ex vivo human skin and reconstructed human skin models from Skinethic. Eilstein J., Léreaux G., Budimir N., Hussler G., Wilkinson S., Duché D., Arch Toxicol, 88, 1681-1694, 2014 .

Skin concentration of topically applied substances in reconstructed human epidermis (RHE) compared with human skin using in vivo confocal Raman microscopy. Fleischli FD., Morf F., Adlhart C., Chimia, 69, 147-151, 2015.

Simultaneous absorption of vitamins C and E from topical emulsions using reconstructed human epidermis as a skin model. B. Rozman, M. Gasperlin, E. Tinois-Tessonneaud, F. Pirot, F. Falson. European Journal of Pharmaceutics and Biopharmaceutics, 72 : 69-75, 2009.