眼刺激性

化学品及原料测试方法(OECD测试指南492)

 

描述

根据OECD测试指南492中SkinEthicTM HCE体外眼刺激性测试方法,基于应用角膜模型的测试结果,对化学物质(液体或固体)进行分类。 


 

模型

 

 
 
  
 
 
 
 

  SkinEthicTM HCE 角膜模型

 

操作原则

SkinEthicTM HCE 角膜模型可以用于体外眼刺激性的评估,应遵循相应的液体或固体物质的SOP操作规范。


详细测试步骤

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参考文献

 

Multi-laboratory validation of SkinEthicTM HCE test method for testing serious eye damage/eye irritation using liquid chemicals. N. Alépée, V. Leblanc, E. Adriaens, M.-H. Grandidier, D. Lelièvre, M. Meloni, L. Nardelli, C.S. Roper, E. Santirocco, F. Toner, A. Van Rompay, J. Vinall, J. Cotovio. Toxicology In Vitro, 31: 43-53, 2016.


Multi-laboratory validation of SkinEthicTM HCE test method for testing serious eye damage/eye irritation using solid chemicals and overall performance of the test method with regard to solid and liquid chemicals testing. N. Alépée, E. Adriaens, M.-H. Grandidier, M. Meloni, L. Nardelli, C. J. Vinall, F. Toner, C. S. Roper, A. R. Van Rompay, V. Leblanc, J Cotovio. Toxicology In Vitro, 34: 55-70, 2016.